A study that was done in 2012 and more recently, ongoing studies look at CBD Oil, as well as other Cannabidiol-containing products and Diabetes. This concerning the endocannabinoid system in the human body. Diabetes refers to a condition that causes the body to be unable to properly process sugar for energy. This in turn can cause high blood glucose and blood sugar levels. Those can result in serious health hazards. Among those are nerve damage, eye problems, heart disease, and even stroke, as blood vessels might get clotted.
1. Type I diabetes is an autoimmune disorder where the body attacks insulin-producing cells. Type I diabetes is thought to be genetic and can be treated with insulin.
2. Type II diabetes, formerly known as adult-onset diabetes, is often associated with obesity. It is characterized by high blood sugar, insulin resistance, and relative lack of insulin.
Excessive thirst and hunger
Frequent urination from urinary tract infections or kidney problems
Weight loss or gain
Fatigue and irritability
Blurred vision
Slow-healing wounds and skin infections
Nausea
Darkening of skin in areas of body creases
Breath odor that is fruity, sweet, or acetone-like
Tingling or numbness in the hands or feet
The endocannabinoid system (ECS) plays a vital role in hunger signals and insulin regulation. The scientist’ also think that an overactive ECS plays a role in obesity and especially in the development of type II diabetes. Thanks to the effects and benefits of CBD Oil on the ECS and receptors, scientists hypothesize that medical marijuana in general and CBD, in particular, can help people with both type I & type II diabetes. Please note that none of the research is currently supported by clinical trials. This accounts for the United States or any other country.
CBD Oil has been shown to decrease levels of resistin (a hormone associated with obesity), as well as increase glucose-dependent insulinotropic peptide. The latter is the hormone responsible for insulin secretion.
Beta cells in the pancreas are responsible for insulin secretion. Many diabetics suffer from pancreatic inflammation due to the destruction of these insulin-producing cells. This is caused by an invasion of immune cells. CBD Oil is shown to reduce pancreatic inflammation, thereby helping to regulate hyperglycemic blood levels.
Oxidative stress and inflammation play a critical role in the development of diabetes and its complications. Recent studies provided compelling evidence that the newly discovered lipid signaling system (ie, the endocannabinoid system) may significantly influence reactive oxygen species production, inflammation, and subsequent tissue injury. This in addition to its well-known metabolic effects and functions. The modulation of the activity of this system holds immense therapeutic potential in a wide range of diseases, including diabetes.
This review focuses on the role of the endocannabinoid system in primary diabetes. It also looks at its effects on various diabetic complications. Those are diabetic cardiovascular dysfunction, nephropathy, retinopathy, and neuropathy. Thereby particularly highlighting the mechanisms beyond the metabolic consequences of the activation of the endocannabinoid system. The therapeutic potential of targeting the endocannabinoid system with certain plant-derived cannabinoids, such as Cannabidiol (CBD) and Δ9-tetrahydrocannabivarin. Those are devoid of psychotropic effects and possess potent anti-inflammatory, as well as antioxidant properties. Their use in diabetes and diabetic complications is also discussed.
Reference: The US National Library of Medicine 2012 – Authors: Béla Horváth, Partha Mukhopadhyay, György Haskó, and Pál Pacher
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