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Cannabidiol (CBD) in the form of CBD Oil and Cannabis flowers to treat Depression. Depression is a term that is often loosely used to describe feeling sad and low. However, major depressive disorder is a much more complicated medical condition. It is a serious mental health disease. Depressive disorder refers to a clinical diagnosis, which is determined by a specific group of symptoms. It allows us to distinguish between the sadness we all feel at times and proper clinical depression. If this applies, a full-spectrum CBD oil and/or CBD-rich Cannabis flowers may be your remedy.
To be diagnosed with a depressive disorder, according to the DSM-5, at least 5 symptoms need to present every day for at least 2 weeks and must cause clinically significant distress or impairment in social, occupational, or other important areas of functioning.
Depressed mood most of the day, nearly every day.
Markedly diminished interest or pleasure in all, or almost all, activities most of the day, nearly every day.
Significant weight loss when not dieting or weight gain, or decrease or increase in appetite nearly every day.
A slowing down of thought and a reduction of physical movement (observable by others, not merely subjective feelings of restlessness or being slowed down).
Fatigue or loss of energy nearly every day.
Feelings of worthlessness or excessive or inappropriate guilt nearly every day.
Diminished ability to think or concentrate, or indecisiveness, nearly every day.
Recurrent thoughts of death, recurrent suicidal ideation without a specific plan, or a suicide attempt or a specific plan for committing suicide.
In the “serotonin hypothesis” of clinical depression, researchers think that a deficit in serotonin activity is a cause of depression. That is why antidepressants such as Selective Serotonin Reuptake Inhibitors (SSRIs) target serotonin receptors. This is in an attempt to increase serotonin levels in the brain. Despite causing fewer side-effects than previous types of antidepressants, SSRIs still come with a baggage of unwanted and adverse effects. This includes an increased risk of suicide.
The cannabis plant (broad-spectrum CBD Oil and Cannabis Flowers) have shown positive effects on treating anxiety and depression. Please note that none of the research is currently supported by full clinical trials, whether in the United States or any other country.
One particular study showed that CBD moderates activation of the 5-HT1A receptors involved in brain development and mood, showing antidepressant effects that are comparable to the well-known antidepressant Imipramine. Furthermore, in a 2016 mouse study, researchers found that serotonin and glutamate levels significantly increased after dosing with CBD.
In a 2011 study, researchers investigated the role of the endocannabinoid system (ECS) in depression and found that a deficiency in endocannabinoids can lead to pre-clinical depression. They also found that CBD restores endocannabinoid signaling similar to conventional antidepressant treatments.