How Can CBD Help against Epilepsy and Epileptic Attacks?

Cannabidiol (CBD), Epilepsy, and Epileptic Attacks are nowadays often mentioned in the same sentence. It looks like Cannabidiol helps in eliminating Epileptic attacks in people. The U.S. Food and Drug Administration (FDA) just approved Epidiolex. A medication based on CBD, and an oral solution for the treatment of seizures associated with Epilepsy and epileptic attacks. In particular, two rare and severe forms of Epilepsy, Lennox-Gastaut syndrome, and Dravet syndrome. The approval is for patients of two years of age and older.  About 4% of people develop Epilepsy during their lifetime. 

This makes it the fourth most common neurological disorder on the planet. Epilepsy is a disorder of the central nervous system’s spectrum. This is characterized by seizures or periods of unusual behavior, sensations, and sometimes, also a complete loss of awareness. 

Treatment of Epilepsy typically focuses on seizure control with medication. 

Seizures that are often symptomatic of Epilepsy are thought to be caused by abnormal brain activity. Brain activity, similar to a kind of electrical storm. In this instance,neurons begin firing in an abnormal, excessive, and synchronized way. However, there are different types of seizures and forms of epilepsies impacting both children and adults.

CBD against Epilepsy and Epileptic Attack
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Common Symptoms of Epilepsy Include

  • Temporary confusion

  • A staring spell

  • Uncontrollable jerking movements of arms and legs

  • Loss of consciousness or awareness

  • Psychic symptoms such as fear, anxiety or Deja-vu 

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How CBD Works for Epilepsy?

Scientists aren’t exactly sure how CBD helps to reduce seizures. Although they think CBD exerts a complex and cumulative effect on a number of physiological systems. They modulate the brain’s overall neural activity and excitability. Scientists hypothesize that the anti-convulsant effects of CBD are potentially due to: 

1. Its ability to inhibit neural activity

CBD is thought to inhibit neuronal activity via GABA receptors. Those are ionotropic receptors responsible for brain activity and excitability.

2. Its ability to modulate intracellular calcium

Cannabidiol also seems to reduce seizure activity by modulating intracellular calcium, as well as reducing neuronal excitability and neuronal transmission. Scientists hypothesize that CBD does this through interactions with targets such as TRP channels. But also, Gcoupled protein receptor protein 55 (GPR55), and/or voltagedependent anionselective channel protein 1 (VDAC1).

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